儿童期腹部放疗后的卵巢功能衰竭。
Ovarian failure following abdominal irradiation in childhood.
作者信息
Shalet S M, Beardwell C G, Jones P H, Pearson D, Orrell D H
出版信息
Br J Cancer. 1976 Jun;33(6):655-8. doi: 10.1038/bjc.1976.103.
Abstract
Ovarian function was studied in 18 female patients treated for abdominal tumours during childhood. All received abdominal radiotherapy as part of their treatment and were studied between 1 and 26 years after irradiation. The serum gonadotrophins and oestradiol levels were consistent with ovarian failure in each case but there was a disproportionate elevation in serum follicle stimulating hormone (FSH) when compared to serum luteinizing hormone (LH) in 16. In 2 patients, the radiotherapeutic field extended downwards only as far as the sacral promontory. However, these 2 girls show similar evidence of ovarian failure to that in the other 16.
摘要
对18名童年期接受腹部肿瘤治疗的女性患者的卵巢功能进行了研究。所有患者均接受腹部放疗作为其治疗的一部分，并在放疗后1至26年进行了研究。每例患者的血清促性腺激素和雌二醇水平均符合卵巢功能衰竭，但16例患者的血清卵泡刺激素（FSH）与血清黄体生成素（LH）相比升高不成比例。2例患者的放疗野仅向下延伸至骶岬。然而，这2名女孩的卵巢功能衰竭证据与其他16例相似。
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