髓母细胞瘤治疗后的生长与内分泌功能
Growth and endocrine function after treatment for medulloblastoma.
作者信息
Brown I H, Lee T J, Eden O B, Bullimore J A, Savage D C
出版信息
Arch Dis Child. 1983 Sep;58(9):722-7. doi: 10.1136/adc.58.9.722.
Abstract
Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children developed growth hormone deficiency. They were clinically euthyroid but 7 had raised basal thyroid stimulating hormone values. Gonadal function was abnormal in all but the youngest child. The rate of survival is increasing in children with medulloblastoma but this is associated with appreciable endocrine abnormalities. Some of these problems are present shortly after treatment ends but others may develop later and long term surveillance is therefore essential.
摘要
布里斯托尔的髓母细胞瘤患儿接受手术、颅脊柱照射治疗，部分患儿还接受化疗。对13名中长期幸存者进行了调查，以确定他们的生长和内分泌功能。在患病的第一年，他们的生长速度大幅下降，脊柱照射后脊柱生长不良。9名儿童出现生长激素缺乏。他们临床甲状腺功能正常，但7名儿童基础促甲状腺激素值升高。除最年幼的儿童外，所有儿童的性腺功能均异常。髓母细胞瘤患儿的生存率在上升，但这与明显的内分泌异常有关。其中一些问题在治疗结束后不久就会出现，但其他问题可能会在以后出现，因此长期监测至关重要。
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本文引用的文献
1
CARCINOMA OF THYROID FOLLOWING IRRADIATION FOR MEDULLOBLASTOMA.髓母细胞瘤放疗后发生的甲状腺癌
Clin Radiol. 1965 Jul;16:282-3. doi: 10.1016/s0009-9260(65)80060-5.
2
Effects of x-irradiation on the hypothalamus: a possible explanation for the therapeutic benefits following x-irradiation of the hypophysial region for pituitary dysfunction.X射线照射对下丘脑的影响：垂体功能障碍患者垂体区域接受X射线照射后治疗效果的一种可能解释。
J Clin Endocrinol Metab. 1954 Aug;14(8):859-68. doi: 10.1210/jcem-14-8-859.
3
The value of myelography in the management of childhood medulloblastoma.
Cancer. 1980 Apr 15;45(8):2194-7. doi: 10.1002/1097-0142(19800415)45:8<2194::aid-cncr2820450831>3.0.co;2-m.
4
Radiation treatment for medulloblastoma. A 21-year review.髓母细胞瘤的放射治疗。一项为期21年的回顾。
J Neurosurg. 1981 Jul;55(1):43-51. doi: 10.3171/jns.1981.55.1.0043.
5
Medulloblastoma in childhood: long-term results of treatment.
Cancer. 1981 Jul 1;48(1):26-30. doi: 10.1002/1097-0142(19810701)48:1<26::aid-cncr2820480107>3.0.co;2-u.
6
Gonadal dysfunction in patients receiving chemotherapy for cancer.接受癌症化疗患者的性腺功能障碍
Ann Intern Med. 1980 Jul;93(1):109-14. doi: 10.7326/0003-4819-93-1-109.
7
The influence of radiation on fertility in man.辐射对人类生育能力的影响。
Br J Radiol. 1980 Apr;53(628):271-8. doi: 10.1259/0007-1285-53-628-271.
8
Correlation of luteinizing hormone-releasing factor-induced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: relation to the restraint of puberty.
J Clin Endocrinol Metab. 1980 Jan;50(1):163-8. doi: 10.1210/jcem-50-1-163.
9
Improvements in the radiotherapy of medulloblastoma, 1946-1975.
Cancer. 1980 Feb 15;45(4):670-8. doi: 10.1002/1097-0142(19800215)45:4<670::aid-cncr2820450409>3.0.co;2-k.
10
Thyroid nodules as a late sequela of radioactive fallout, In a Marshall Island population exposed in 1954.
N Engl J Med. 1966 Jun 23;274(25):1391-9. doi: 10.1056/NEJM196606232742501.
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