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白及作为栓塞剂在肝癌介入治疗中的新应用

[New use of Bletilla striata as embolizing agent in the intervention treatment of hepatic carcinoma].

作者信息

Zheng C, Feng G, Zhou R

机构信息

Department of Radiology, Union Hospital of Tongji Medical University, Wuhan.

出版信息

Zhonghua Zhong Liu Za Zhi. 1996 Jul;18(4):305-7.

PMID:9387329
Abstract

A Chinese herb, Bletilla striata, was used as embolizing agent in order to improve the therapeutic results of intervention treatment of liver cancer. From October 1991 to January 1995, 56 cases of hepatic carcinoma were treated with Bletilla striata by hepatic artery embolization, with conventional gelform embolization in 50 cases as control. Patients were followed-up for 10-48 months. Embolization with Bletilla striata led to extensive and permanent vascular obstruction, accompanied with marked shrinkage of tumor size and significant decrease in serum AFP levels. Collaterals were few in number and collateral circulation was established late so that the treatment intervals could be prolonged, with an average of 7 months. The 1-, 2-, and 3-year survival rate was 81.9%, 44.9% and 33.6%, respectively, with a median survival time of 19.8 months. All the clinical parameters were better than those treated with conventional gelform embolization. The results indicate that Bletilla striata is an ideal vascular embolizing agent.

摘要

一种中草药白芨被用作栓塞剂,以提高肝癌介入治疗的效果。1991年10月至1995年1月,对56例肝癌患者采用白芨进行肝动脉栓塞治疗,50例采用常规明胶海绵栓塞作为对照。对患者进行了10至48个月的随访。白芨栓塞导致广泛且持久的血管阻塞,伴有肿瘤大小明显缩小和血清甲胎蛋白水平显著下降。侧支血管数量少且侧支循环建立较晚,从而可延长治疗间隔时间,平均为7个月。1年、2年和3年生存率分别为81.9%、44.9%和33.6%,中位生存时间为19.8个月。所有临床指标均优于常规明胶海绵栓塞治疗的患者。结果表明白芨是一种理想的血管栓塞剂。

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