[Experimental study on the effects of FGF on the changes in vascular architecture of subdermal vascular plexus of the thin skin flap].

In this experimental study, eight rabbits were used to investigate the survival mechanism of subdermal vascular plexus thin skin flap. By histological, immunohistochemical and microcirculatory observation, we found that the vascular architecture of different parts of the flap had great dissimilarity: the vascular architecture of the proximal part was same as that of normal skin, the middle one showed extremely active angiogenesis, and the distal part also showed angiogenesis but in medium level. We conclude that the middle part of the flap works as an "intermediary pedicle", and is the basis of the early pedicle division and superior survival ratio of the flap. The fibroblast growth factor (FGF) plays an important role in the changes in vascular architecture of the flap.