Song Y, Xiu Z, Zhang Z
Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1996 Sep;12(5):323-5.
In this experimental study, eight rabbits were used to investigate the survival mechanism of subdermal vascular plexus thin skin flap. By histological, immunohistochemical and microcirculatory observation, we found that the vascular architecture of different parts of the flap had great dissimilarity: the vascular architecture of the proximal part was same as that of normal skin, the middle one showed extremely active angiogenesis, and the distal part also showed angiogenesis but in medium level. We conclude that the middle part of the flap works as an "intermediary pedicle", and is the basis of the early pedicle division and superior survival ratio of the flap. The fibroblast growth factor (FGF) plays an important role in the changes in vascular architecture of the flap.
在本实验研究中，八只兔子被用于研究皮下血管丛薄皮瓣的存活机制。通过组织学、免疫组织化学及微循环观察，我们发现皮瓣不同部位的血管结构存在很大差异：近端部分的血管结构与正常皮肤相同，中间部分显示出极其活跃的血管生成，而远端部分也显示出血管生成但程度中等。我们得出结论，皮瓣的中间部分起着“中间蒂”的作用，是皮瓣早期断蒂及较高存活率的基础。成纤维细胞生长因子（FGF）在皮瓣血管结构变化中起重要作用。
