[麻醉犬在呼气末正压通气负荷时内脏器官传出交感神经活动的反射性变化]
[Reflex changes in efferent sympathetic nerve activities of visceral organs during PEEP loading in anesthetized dogs].
作者信息
Hu H, Miyasaka K, Liu Y
机构信息
Department of Pulmonary Medicine, Chinese PLA Genaral Hospital, Beijing.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1996 Jun;19(3):161-4.
OBJECTIVE
To study the effects of PEEP 0.98 kPa (1 kPa = 10.2 cmH2O) on the sympathetic nerve activities of visceral organs in anesthetized dogs with intact neuraxis or with vagotomy.
METHODS
Renal (RNA), cardiac (CNA), hepatic (HNA) and adrenal gland (AdNA) sympathetic nerve activities were recorded. Mean blood pressure (MBP), central venous pressure (CVP), left atrial pressure (LAP) and airway pressure (AWP) were also measured.
RESULTS
AdNA significantly decreased, but RNA, CNA and HNA had a tendency toward decrease during PEEP loading in the intact dogs. However, vagotomy reversed the changes in all nerve activities in the intact dogs. CVP, LAP and AWP significantly increased, while MBP significantly decreased during PEEP loading.
CONCLUSION
The results indicated that PEEP loading caused sympathoinhibition in the adrenal gland, kidney, heart and liver, which were mediated by activation of cardiopulmonary baroreceptor.
目的
研究0.98 kPa（1 kPa = 10.2 cmH₂O）的呼气末正压通气（PEEP）对神经轴完整或迷走神经切断的麻醉犬内脏器官交感神经活动的影响。
方法
记录肾（RNA）、心脏（CNA）、肝脏（HNA）和肾上腺（AdNA）的交感神经活动。同时测量平均血压（MBP）、中心静脉压（CVP）、左心房压（LAP）和气道压（AWP）。
结果
在神经轴完整的犬中，PEEP加载期间AdNA显著降低，但RNA、CNA和HNA有降低趋势。然而，迷走神经切断逆转了神经轴完整犬中所有神经活动的变化。PEEP加载期间CVP、LAP和AWP显著升高，而MBP显著降低。
结论
结果表明，PEEP加载引起肾上腺、肾脏、心脏和肝脏的交感抑制，这是由心肺压力感受器的激活介导的。
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