Chi J, Tang W, Sun M
Department of Endocrinology, Beijing Hospital.
Zhonghua Nei Ke Za Zhi. 1996 Apr;35(4):246-8.
To study the relationship of the concentration of serum lipoprotein (a) [Lp(a)] with diabetic complications in non-insulin dependent diabetes mellitus (NIDDM), 100 non-diabetics with 150 patients with NIDDM were compared. There was no difference in Lp(a) concentration (P > 0.5) between the two groups. Lp(a) concentration was not significantly correlated with the levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein A-I, apolipoprotein B in both groups. In NIDDM group, patients with hypertension, macro- and microangiopathy had higher levels of Lp(a) than those without these complications (P < 0.001 and P = 0.002 respectively). Lp(a) level was positively related to presence of macroangiopathy (r = 0.185, P = 0.024) and proteinuria (r = 0.316, P < 0.001) in NIDDM.
为研究非胰岛素依赖型糖尿病（NIDDM）患者血清脂蛋白（a）[Lp（a）]浓度与糖尿病并发症之间的关系，对100名非糖尿病患者和150名NIDDM患者进行了比较。两组之间的Lp（a）浓度无差异（P>0.5）。两组中Lp（a）浓度与总胆固醇、低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、HDL2-C、HDL3-C、载脂蛋白A-I、载脂蛋白B水平均无显著相关性。在NIDDM组中，患有高血压、大血管和微血管病变的患者的Lp（a）水平高于无这些并发症的患者（分别为P<0.001和P = 0.002）。在NIDDM中，Lp（a）水平与大血管病变的存在（r = 0.185，P = 0.024）和蛋白尿（r = 0.316，P<0.001）呈正相关。
