Okubo T, Narita Y, Okushiba T, Doke M, Takahashi T, Okusiba S, Motohara T, Katoh H
Second Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Kyobu Geka. 1997 Nov;50(12):991-6.
Sixteen cases of primary lung cancer in patients younger than 40 years old had been operated on at the department. There were 8 males and 8 females and the male-to-female ratio was 1:1 that was closer than the ratio in elder patients over 40 years. Histologic types were adenocarcinoma in 7 cases, squamous carcinoma in 5 cases, carcinoid in 2 cases, and small cell carcinoma in 2 cases. In younger patients, adenocarcinomas, small cell carcinomas, and carcinoids were more commonly found than squamous cell carcinomas. Patients in stage I, II, and IIIA and those undergoing a curative resection were predominant in cases without any symptoms preoperatively. The 5-year survival rate of the 16 patients younger than 40 years was 42.9%, that was not significantly different from that of elder patients over 40 years old. This relatively better prognosis might be owing to a fact that operated patients were dominantly composed of asymptomatic patients. In younger patients who have good physical status and respiratory function compared with elder patients, aggressive surgical diagnosis followed by resection, if the definitive diagnosis of malignancy is established may contribute to the improvement of prognosis for patients who was suspected of having malignancy.
该科室已为16例40岁以下的原发性肺癌患者实施了手术。其中男性8例，女性8例，男女比例为1:1，这一比40岁以上老年患者的比例更为接近。组织学类型为腺癌7例，鳞癌5例，类癌2例，小细胞癌2例。在年轻患者中，腺癌、小细胞癌和类癌比鳞癌更为常见。I期、II期和IIIA期且接受根治性切除的患者在术前无症状的病例中占主导地位。16例40岁以下患者的5年生存率为42.9%，与40岁以上老年患者的生存率无显著差异。这种相对较好的预后可能是由于手术患者主要由无症状患者组成。与老年患者相比，年轻患者身体状况和呼吸功能良好，如果确诊为恶性肿瘤，积极进行手术诊断并随后切除，可能有助于改善疑似患有恶性肿瘤患者的预后。
