Toba K, Sudoh N, Nagano K, Eto M, Mizuno Y, Nakagawa H, Kawabata Y, Yamami N, Hara M, Fukushima Y, Ouchi Y
Department of Geriatrics, Faculty of Medicine, University of Tokyo.
Nihon Ronen Igakkai Zasshi. 1997 Jul;34(7):577-82. doi: 10.3143/geriatrics.34.577.
A randomized prospective study was done to evaluate the two treatments for pressure sores infected with methicillin-resistant Staphylococcus aureus in elderly patients: Gentian violet plus dibutyryl cAMP (GVcAMP, n = 8) and povidone-iodine plus sugar (IS, n = 11). Age, underlying diseases, and nutritional status did not differ between the two groups. Specimens were obtained biweekly from the pressure sores and were cultured. The percentage of culture dishes with no methicillin-resistant S. aureus was 93% for the patients given GVcAMP, but only 74% for those given IS (p < 0.01). By the 14th week after the start of treatment, the mean area of the pressure sores in the GVcAMP group had decreased to 45% of the area at the start of treatment. In the IS group, the decrease was smaller to 56% of the area before treatment. No local or systemic adverse effects occurred in either group. GVcAMP is useful to treat pressure sores infected with methicillin-resistant S. aureus.
进行了一项随机前瞻性研究，以评估老年患者耐甲氧西林金黄色葡萄球菌感染的压疮的两种治疗方法：龙胆紫加二丁酰环磷腺苷（GVcAMP，n = 8）和聚维酮碘加糖（IS，n = 11）。两组患者的年龄、基础疾病和营养状况无差异。每两周从压疮处采集标本并进行培养。接受GVcAMP治疗的患者，无耐甲氧西林金黄色葡萄球菌生长的培养皿百分比为93%，而接受IS治疗的患者仅为74%（p < 0.01）。治疗开始后第14周，GVcAMP组压疮的平均面积降至治疗开始时面积的45%。在IS组，下降幅度较小，为治疗前面积的56%。两组均未出现局部或全身不良反应。GVcAMP可有效治疗耐甲氧西林金黄色葡萄球菌感染的压疮。
