Saji M, Taguchi S, Uchiyama K, Osono E, Hayama N, Ohkuni H
Section of Pharmaceutics, First Hospital of Nippon Medical School, Tokyo, Japan.
J Hosp Infect. 1995 Nov;31(3):225-8. doi: 10.1016/0195-6701(95)90070-5.
The efficacy of gentian violet (Gv) in eradicating methicillin-resistant Staphylococcus aureus (MRSA) in decubitus ulcers was investigated. Decubitus ulcers (a total of 18 cases) were scrubbed with Gv aqueous solution 0.1% and ointment containing Gv 0.1% was applied daily. MRSA was not detected in these lesions for 3-34 days (average, 10.5 +/- 2.5 days) after the application of Gv ointment. Before this trial, all patients were treated with povidone-iodine and antibiotics; however, those treatments were not effective in eradicating MRSA from skin lesions. Skin irritation and other systemic side effects caused by Gv were not observed. Our data suggest that Gv is a useful agent for treatment of the decubitus ulcers infected with MRSA.
研究了龙胆紫（Gv）根除压疮中耐甲氧西林金黄色葡萄球菌（MRSA）的疗效。对18例压疮患者用0.1%的Gv水溶液进行擦洗，并每日涂抹含0.1%Gv的软膏。在涂抹Gv软膏后3 - 34天（平均10.5±2.5天），这些损伤部位未检测到MRSA。在该试验之前，所有患者均接受聚维酮碘和抗生素治疗；然而，这些治疗方法未能有效根除皮肤损伤部位的MRSA。未观察到Gv引起的皮肤刺激和其他全身副作用。我们的数据表明，Gv是治疗感染MRSA的压疮的有效药物。
