Ishii T, Tatezaki S, Satoh T, Yonemoto T, Umeda T, Kitoh M
Division of Orthopedic Surgery, Chiba Cancer Center Hospital.
Gan To Kagaku Ryoho. 1997 Nov;24(14):2123-30.
From January 1990 to December 1995 we treated 35 patients (pts) with bone and soft tissue sarcoma with ifosfamide (IFM). Sixteen patients had measurable metastatic pulmonary lesion and 9 had primary lesion. Histology of the tumor included osteosarcoma in 13 pts, Ewing sarcoma in 5 pts, malignant fibrous histiocytoma of bone in 2 pts, synovial sarcoma in 7pts, primitive neuroectodermal tumor in 2 pts, and other in 7 pts. The IFM at the dose of 12-18g/m2 (mean 15. 4g/m2) for 5 to 8 days continuous infusion was administered to patients in each treatment course. The uroprotector, mesna, was also given concomitantly in 60-100% dose of IFM. Eighteen pts received one course of IFM treatment. Other pts received 2 to 8 courses of IFM treatment at three to four week intervals. The overall response rate was 40% (PR in 14 pts, NC in 18 pts, and PD in 3 pts). The response rate of 13 pts with osteosarcoma was 54% (PR in 7 pts) and 30% in 15 pts with soft tissue sarcoma (PR in 5 pts).
1990年1月至1995年12月，我们用异环磷酰胺（IFM）治疗了35例骨肉瘤和软组织肉瘤患者。16例患者有可测量的肺转移病灶，9例有原发灶。肿瘤组织学类型包括骨肉瘤13例、尤因肉瘤5例、骨恶性纤维组织细胞瘤2例、滑膜肉瘤7例、原始神经外胚层肿瘤2例、其他7例。每个疗程对患者持续输注剂量为12 - 18g/m²（平均15.4g/m²）的IFM，持续5至8天。同时还给予剂量为IFM 60 - 100%的尿路保护剂美司钠。18例患者接受了一个疗程的IFM治疗。其他患者每隔三到四周接受2至8个疗程的IFM治疗。总有效率为40%（14例部分缓解，18例病情稳定，3例疾病进展）。13例骨肉瘤患者的有效率为54%（7例部分缓解），15例软组织肉瘤患者的有效率为30%（5例部分缓解）。
