异环磷酰胺在肉瘤治疗中的作用。
The role of ifosfamide in the treatment of sarcomas.
作者信息
Dirix L Y, Van Oosterom A T
机构信息
Department of Oncology, Antwerp University Hospital, Edegem, Belgium.
出版信息
Semin Oncol. 1989 Feb;16(1 Suppl 3):39-45.
PMID:2649984
Abstract
The alkylating agent ifosfamide has demonstrated significant activity against advanced sarcomas. In advanced soft tissue sarcomas, doxorubicin and ifosfamide are the most active single agents. Their combination results in response rates of 34% to 41% in various trials. In advanced osteosarcoma and Ewing's sarcoma, ifosfamide also is active. In Ewing's sarcoma, the above combination with etoposide has resulted in high response rates.
摘要
烷化剂异环磷酰胺已显示出对晚期肉瘤有显著活性。在晚期软组织肉瘤中，多柔比星和异环磷酰胺是最具活性的单一药物。在各种试验中，它们联合使用的缓解率为34%至41%。在晚期骨肉瘤和尤因肉瘤中，异环磷酰胺也具有活性。在尤因肉瘤中，上述与依托泊苷联合使用已产生高缓解率。
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