Martín-Blanco E
Department of Zoology, University of Cambridge, UK.
Curr Opin Genet Dev. 1997 Oct;7(5):666-71. doi: 10.1016/s0959-437x(97)80015-9.
Recent studies have defined a new Drosophila Jun amino-terminal kinase (DJNK) pathway. The first role that has been uncovered for this pathway is the control of cell differentiation and morphogenesis during the process of dorsal closure. This phosphorylation cascade has been conserved during evolution and several reports suggest that it becomes activated in response to the action of small GTPases. DJNK signalling impinges on transcription factors as DJun and Anterior open and eventually controls the expression of target genes such as decapentaplegic and puckered. Important progress has been made in the study of the coordination of DJNK and Decapentaplegic signalling during dorsal closure and their role in the control of cell shape changes--and possibly cell polarity--by promoting cytoskeletal changes.
最近的研究确定了一种新的果蝇JNK（DJNK）信号通路。该通路被发现的首个作用是在背闭合过程中控制细胞分化和形态发生。这种磷酸化级联反应在进化过程中得以保留，并且有几份报告表明它会响应小GTP酶的作用而被激活。DJNK信号传导作用于转录因子如DJun和Anterior open，最终控制靶基因如dpp（decapentaplegic）和puc（puckered）的表达。在背闭合过程中DJNK和dpp信号传导的协调研究以及它们通过促进细胞骨架变化来控制细胞形状改变——可能还有细胞极性——的作用方面已经取得了重要进展。
