Wu T, Sha Y, Han F, Duan J, Cheng J
National Research Institute for Family Planning, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1996 Oct;18(5):375-9.
It has been reported that gossypol acetic acid (GAA) inhibits sperm motility and calcium plays an important role in regulating the function of the sperm flagella. In order to explore the mechanism by which GAA inhibits sperm motility, the effects of GAA on human ejaculated sperm Ca2+ influx and isolated rat vas deferens contraction action were studied. The results showed that GAA inhibited sperm Ca2+ influx in a dose-dependent manner, and breaked the dynamic equilibrium of sperm internal and external Ca2+ gradient concentrations. It may be one of important mechanism by which GAA inhibits sperm motility. But GAA exerts no effect on the high K+ induced contraction of smooth muscle of isolated rat vas deferens. It is likely that GAA has selective action on the sperm membrane of the rats.
据报道，醋酸棉酚（GAA）会抑制精子活力，而钙在调节精子鞭毛功能中起着重要作用。为了探究GAA抑制精子活力的机制，研究了GAA对人射出精子Ca2+内流及离体大鼠输精管收缩作用的影响。结果表明，GAA以剂量依赖性方式抑制精子Ca2+内流，打破了精子内外Ca2+梯度浓度的动态平衡。这可能是GAA抑制精子活力的重要机制之一。但GAA对高钾诱导的离体大鼠输精管平滑肌收缩无作用。GAA可能对大鼠精子膜有选择性作用。
