Lei H Q, Xu Y X
Department of Pharmacology, Xi'an Medical University.
Yao Xue Xue Bao. 1993;28(1):6-10.
The effects of gossypol acetic acid (GAA) on the contractile activity of rat oviduct smooth muscle were studied in vitro with an attempt to clarify its mechanism of action. The result showed that GAA apparently increased the contractile tension of oviduct smooth muscle. This effect was not the result of excitation of the alpha-adrenergic receptor, but due to promotion of PGs biosynthesis and release. It might also be related to an increase in Ca2+ influx in the tissue. The pharmacological effect of GAA was also shown to be relevant to sexual cycle. The action of increasing contractile tension by GAA on the estrus duct was much larger than that on the diestrus duct. In addition, the results indicate that PGE1 and PGE2 increased the contractile activity of oviduct, the action of PGE1 was more potent than that of PGE2, and this effect was found to be increased significantly by GAA.
为阐明醋酸棉酚（GAA）对大鼠输卵管平滑肌收缩活动的作用机制，进行了体外实验研究。结果显示，GAA可显著增加输卵管平滑肌的收缩张力。该作用并非α-肾上腺素能受体兴奋的结果，而是由于促进了前列腺素（PGs）的生物合成与释放。这可能还与组织中Ca2+内流增加有关。GAA的药理作用还显示与性周期有关。GAA对发情期输卵管增加收缩张力的作用比对间情期输卵管的作用大得多。此外，结果表明，前列腺素E1（PGE1）和前列腺素E2（PGE2）可增加输卵管的收缩活动，PGE1的作用比PGE2更强，且发现GAA可显著增强这种作用。
