Sato A, Sato Y, Shimada F, Torigata Y
Brain Res. 1976 Jul 9;110(2):301-11. doi: 10.1016/0006-8993(76)90404-2.
The effect of nociceptive stimulation of various skin areas of the neck, chest and abdomen on the heart rate was examined in anesthetized rats with the cord intact and in acute spinal rats, at different body temperatures. In the anesthetized rats with the cord intact, the stimulation on the neck, chest and abdominal skin areas caused reflex changes in heart rate. At a rectal temperature of 38.0-38.9 degrees C the response was usually an increase in heart rate, whereas the response at 36.0-36.9 degrees C was a decrease. The heart rate reflex response at 37.0-37.9 degrees C was a monophasic increase or decrease, or a biphasic initial decrease followed by an increase. The reflex increase or decrease in heart rate produced by cutaneous stimulation was mediated by a reflex increase or decrease in the efferent discharges of the cardiac sympathetic nerve. In acute spinal rats, only stimulation on the chest skin area, at a rectal temperature of 36.0-38.9 degrees C, would always produce a reflex increase in heart rate. This reflex increase in heart rate was also produced by an increase in efferent discharges of the cardiac sympathetic nerve.
在不同体温下，对脊髓完整的麻醉大鼠和急性脊髓损伤大鼠，研究了颈部、胸部和腹部不同皮肤区域的伤害性刺激对心率的影响。在脊髓完整的麻醉大鼠中，对颈部、胸部和腹部皮肤区域的刺激会引起心率的反射性变化。直肠温度在38.0 - 38.9摄氏度时，反应通常是心率增加，而在36.0 - 36.9摄氏度时，反应是心率降低。在37.0 - 37.9摄氏度时，心率反射反应是单相增加或降低，或双相的先降低后增加。皮肤刺激引起的心率反射性增加或降低是由心脏交感神经传出放电的反射性增加或降低介导的。在急性脊髓损伤大鼠中，只有在直肠温度为36.0 - 38.9摄氏度时，对胸部皮肤区域的刺激才会总是引起心率反射性增加。这种心率反射性增加也是由心脏交感神经传出放电增加引起的。
