Faas M M, Schuiling G A, Baller J F, Valkhof N, Bakker W W
Department of Pathology, University of Groningen, The Netherlands.
J Lab Clin Med. 1997 Nov;130(5):496-508. doi: 10.1016/s0022-2143(97)90126-8.
In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular inflammation in pregnant rats infused with low-dose endotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endotoxin (ET rats) or saline (control rats) and received ASA in their drinking water. These rats were compared with non-ASA-treated rats. Blood pressure and albumin excretion were measured from day 15 to day 21, and glomerular fibrinogen and ecto-ADPase activity were measured at day 21. Glomerular inflammation was evaluated at various times after the start of the infusion. The results show that treatment with ASA had a significant beneficial effect on hypertension and inflammation induced by endotoxin in pregnant rats, whereas it reduced albumin excretion and glomerular fibrinogen deposits in some of the rats.
在本研究中，我们评估了低剂量阿司匹林（乙酰水杨酸（ASA）；每日1.0毫克/千克）对血压、白蛋白排泄、肾小球纤维蛋白原沉积、肾小球（基底）膜结合腺苷二磷酸酶（胞外ADP酶）活性以及对输注低剂量内毒素（1.0毫克/千克）的妊娠大鼠肾小球炎症的影响。大鼠（妊娠第14天）被输注内毒素（ET大鼠）或生理盐水（对照大鼠），并在饮用水中给予ASA。将这些大鼠与未接受ASA治疗的大鼠进行比较。在第15天至第21天测量血压和白蛋白排泄，并在第21天测量肾小球纤维蛋白原和胞外ADP酶活性。在输注开始后的不同时间评估肾小球炎症。结果表明，ASA治疗对妊娠大鼠内毒素诱导的高血压和炎症有显著有益作用，而在一些大鼠中它降低了白蛋白排泄和肾小球纤维蛋白原沉积。
