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原胶原蛋白促黑素皮质激素原(POMC)在非洲肺鱼——非洲肺鱼的卵巢中的表达及POMC相关肽的免疫定位

Pro-opiomelanocortin (POMC) expression and immunolocalization of POMC-related peptides in the ovary of Protopterus annectens, an African lungfish.

作者信息

Masini M A, Sturla M, Pestarino M, Gallinelli A, Facchinetti F, Uva B M

机构信息

Istituto di Anatomia Comparata, Università di Genova, Italy.

出版信息

Peptides. 1997;18(9):1411-4. doi: 10.1016/s0196-9781(97)00200-3.

DOI:10.1016/s0196-9781(97)00200-3
PMID:9392844
Abstract

Antisera against adrenocorticotropic hormone (ACTH), alpha-melanocyte-stimulating hormone (alpha MSH) and beta-endorphin were used to localize pro-opiomelanocortin (POMC)-derived peptides in the ovary of the African lungfish Protopterus annectens by immunohistochemistry. Immunoreactivity was observed in the granulosa and the internal theca of the vitellogenic follicles. No immunoreactivity was observed in immature follicles. Using human POMC cDNA as the hybridization probe POMC-like mRNA was identified in situ in cells of the granulosa and internal theca of the vitellogenic follicles. No labeling was observed in primordial follicles. The demonstration in the same cells of POMC mRNA and POMC-related peptides immunoreactivity indicates a local production of the opiate hormones.

摘要

通过免疫组织化学方法,使用抗促肾上腺皮质激素(ACTH)、α-黑素细胞刺激素(αMSH)和β-内啡肽的抗血清,在非洲肺鱼原鳍鱼的卵巢中定位源自阿片-促黑素细胞皮质素原(POMC)的肽。在卵黄生成卵泡的颗粒细胞和内膜中观察到免疫反应性。在未成熟卵泡中未观察到免疫反应性。使用人POMC cDNA作为杂交探针,在卵黄生成卵泡的颗粒细胞和内膜细胞中原位鉴定出POMC样mRNA。在原始卵泡中未观察到标记。在相同细胞中POMC mRNA和POMC相关肽免疫反应性的证明表明阿片类激素是局部产生的。

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