北美本土药用植物刺人参中的抗分枝杆菌聚炔类化合物。
Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.
作者信息
Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock R E, Towers G H, Doxsee D, Stokes R W
机构信息
Botany and Microbiology, University of British Columbia, Vancouver, Canada.
出版信息
J Nat Prod. 1997 Nov;60(11):1210-3. doi: 10.1021/np970182j.
Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay.
从北美药用植物刺人参（五加科刺人参属）中分离出两种新的聚乙炔化合物（3和5）以及三种已知的聚乙炔化合物（1、2和4）。通过¹H和¹³C核磁共振确定了其结构。应用莫舍尔方法确定了2和5的绝对构型。所有聚乙炔化合物均表现出显著的抗念珠菌、抗菌和抗分枝杆菌活性，在纸片扩散试验中，浓度为10微克/纸片时能够杀死结核分枝杆菌和耐异烟肼鸟分枝杆菌。
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