使用不同剂量肝细胞特异性造影剂FP 736 - 03的CT检查。在实验性转移裸鼠模型中的评估
CT with different doses of the hepatocyte-specific contrast medium FP 736-03. Evaluation in a nude-rat model of experimental metastases.
作者信息
Bergman A, Sundin A, Magnusson A
机构信息
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
出版信息
Acta Radiol. 1997 Nov;38(6):1003-6. doi: 10.1080/02841859709172118.
PURPOSE
To study the dose-response relationship in FP 736-03 (48 mg I/ml), hepatocyte-specific contrast medium for CT of the liver.
MATERIAL AND METHODS
A nude-rat model of experimental hepatic metastases was used. CT of the liver was performed before and after i.v. injection of FP 736-03 at 4 different doses: 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. Attenuation in the normal liver parenchyma and in the metastases was measured and plotted as a function of time.
RESULTS
The enhancement of the normal liver parenchyma increased in the dose range studied. No increase was found in the metastases: the attenuation here remained constant during the observation period. The maximum enhancement values at doses of 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. were (mean +/- SD) 13.5 +/- 2.7, 30.1 +/- 4.2, 33.2 +/- 4.5 and 59.7 +/- 13.1 HU respectively.
目的
研究用于肝脏CT检查的肝细胞特异性造影剂FP 736 - 03（48 mg碘/毫升）的剂量-反应关系。
材料与方法
采用裸鼠实验性肝转移模型。静脉注射4种不同剂量（0.25、0.5、1.0和2.0毫升/千克体重）的FP 736 - 03前后进行肝脏CT检查。测量正常肝实质和转移灶的衰减，并将其绘制成时间的函数。
结果
在所研究的剂量范围内，正常肝实质的强化增加。转移灶未见强化增加：在观察期内其衰减保持恒定。剂量为0.25、0.5、1.0和2.0毫升/千克体重时的最大强化值分别为（平均值±标准差）13.5±2.7、30.1±4.2、33.2±4.5和59.7±13.1 HU。
Zotero 插件