使用肝细胞特异性对比剂FP 736 - 03在CT上检测实验性肝转移灶。
Detecting experimental liver metastases at CT with the hepatocyte-specific contrast medium FP 736-03.
作者信息
Bergman A, Magnusson A, Sundin A
机构信息
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
出版信息
Acta Radiol. 1998 Jul;39(4):381-3. doi: 10.1080/02841859809172449.
PURPOSE
To evaluate the detection of experimental hepatic metastases at CT with the hepatocyte-specific contrast medium FP 736-03.
MATERIAL AND METHODS
A nude-rat model of experimental multiple hepatic metastases from a human colonic cancer was used. Three weeks after intraportal tumour cell injection, the CT examination was performed before and after i.v. injection of FP 736-03 at a dose of 0.5 ml/kg b.w.
RESULTS
The overall detection rate was determined in a lesion-by-lesion analysis of 87 metastases. Irrespective of metastatic size, the mean detection rate for two viewers was significantly higher at the FP-736-03-enhanced examination (59%) than at the unenhanced CT examination (16%).
CONCLUSION
The detection rate increased with the i.v. administration of FP 736-03 at a dose of 0.5 ml/kg b.w. compared with that at unenhanced examination.
目的
评估使用肝细胞特异性对比剂FP 736 - 03进行CT检查对实验性肝转移瘤的检测效果。
材料与方法
采用人结肠癌实验性多灶性肝转移裸鼠模型。门静脉内注射肿瘤细胞三周后，静脉注射剂量为0.5 ml/kg体重的FP 736 - 03前后进行CT检查。
结果
对87个转移灶进行逐个分析确定总体检测率。无论转移瘤大小，两名观察者在FP - 736 - 03增强检查时的平均检测率（59%）显著高于未增强CT检查时的平均检测率（16%）。
结论
与未增强检查相比，静脉注射剂量为0.5 ml/kg体重的FP 736 - 03时检测率提高。
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