Ueda J, Furukawa T, Higashino K, Takahashi S, Araki Y, Kubo K, Nakashima T
Department of Radiology, Sumitomo Hospital, Nara Medical University, Japan.
Acta Radiol. 1997 Nov;38(6):1079-82. doi: 10.1080/02841859709172135.
Previous observations in rats caused us to speculate whether the injection of iotrolan, a nonionic dimeric contrast medium (CM), would increase urine viscosity enough to obstruct urine outflow in the collecting duct.
The urine viscosity in dogs was measured directly with a viscosimeter after injections of iotrolan or of iomeprol, a nonionic monomeric CM.
The injection of iotrolan increased urine viscosity considerably whereas iomeprol had little effect on this variable. The osmolality-dependent adverse reactions of CM have previously been emphasized but viscosity-dependent adverse reactions must also be considered when the CM is a polymer with a low osmolality.
