Jazin E E, Söderström S, Ebendal T, Larhammar D
Department of Medical Genetics, Uppsala University, Sweden.
J Neuroimmunol. 1997 Nov;79(2):148-54. doi: 10.1016/s0165-5728(97)00117-3.
We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.
我们之前克隆了一种人类受体，最近发现它是T嗜性HIV-1毒株进入CD4+细胞的辅助因子，现命名为融合素。基质衍生因子-1（SDF-1）是融合素的内源性配体，也称为CXCR-4。在此我们展示了融合素/CXCR-4 mRNA在大鼠个体发育过程中的分布。mRNA表达起始于胚胎第9天左右，在发育过程中，胸腺以及大脑的增殖区域中mRNA表达水平较高。我们的结果表明：（1）融合素/CXCR-4可能在大脑发育和免疫系统中都具有双重作用；（2）SDF-1在大脑发育中发挥作用，或者该受体存在其他生理配体；（3）CD4与融合素/CXCR-4的共表达可能使胎儿在发育过程中易受HIV感染。
