Molecular Neurotherapy and Imaging Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Neuroscience. 2011 Dec 1;197:37-47. doi: 10.1016/j.neuroscience.2011.08.063. Epub 2011 Sep 14.
Stem cells have a number of properties, which make them excellent candidates for the treatment of various neurologic disorders, the most important of which being their ability to migrate to and differentiate predictably at sites of pathology in the brain. The disease-directed migration and well-characterized differentiation patterns of stem cells may eventually provide a powerful tool for the treatment of both localized and diffuse disease processes within the human brain. A thorough understanding of the molecular mechanisms governing their migratory properties and their choice between different differentiation programs is essential if these cells are to be used therapeutically in humans. This review focuses on summarizing the migration and differentiation of therapeutic neural and mesenchymal stem cells in different disease models in the brain and also discusses the promise of these cells to eventually treat various forms of neurologic disease.
干细胞具有多种特性，使其成为治疗各种神经疾病的理想候选者，其中最重要的特性是它们能够迁移到大脑病变部位并可预测地分化。干细胞的疾病定向迁移和特征明确的分化模式最终可能为治疗人脑内局部和弥漫性疾病提供强有力的工具。如果要在人类中对这些细胞进行治疗，就必须深入了解控制其迁移特性的分子机制及其在不同分化程序之间的选择。本综述重点总结了治疗性神经和间充质干细胞在大脑不同疾病模型中的迁移和分化，并讨论了这些细胞最终治疗各种形式的神经疾病的前景。
