新生儿内源性一氧化氮生成的评估：尿中亚硝酸盐和硝酸盐浓度的测定。

Assessment of endogenous nitric oxide formation in newborns: measurement of urinary nitrite and nitrate concentrations.

作者信息

Tsukahara H, Takeuchi M, Hata I, Hiraoka M, Kotsuji F, Sudo M, Mayumi M

机构信息

Department of Pediatrics, Fukui Medical School, Japan.

出版信息

Biol Neonate. 1997;72(5):322-6. doi: 10.1159/000244499.

DOI:10.1159/000244499

PMID:9395843

Abstract

We measured the urinary nitrite and nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NOx- excretion significantly increased from the 1st to the 4th day. The urinary NOx- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NOx- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NOx- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.

摘要

我们测量了足月儿和早产儿出生第1天及第4天时尿中亚硝酸盐和硝酸盐（NOx-）的排泄量，这是内源性一氧化氮生成的一个指标。在两组婴儿中，尿中NOx-排泄量从第1天到第4天均显著增加。在这两天，早产儿的尿NOx-排泄量均显著高于足月儿。此外，在第4天，患有呼吸窘迫综合征的早产儿与无心肺并发症的早产儿相比，尿NOx-排泄量显著升高。新生儿尿NOx-排泄量的这些变化有力地表明，一氧化氮在循环系统适应宫外生活中发挥着积极的生理作用。