Tsukahara H, Hiraoka M, Hori C, Tsuchida S, Hata I, Nishida K, Kikuchi K, Sudo M
Department of Pediatrics, Fukui Medical School, Japan.
Early Hum Dev. 1997 Jan 3;47(1):51-6. doi: 10.1016/s0378-3782(96)01768-9.
We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months. In normal term infants, urinary NOx excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.
我们测量了足月儿和早产儿在1周龄以及1、4、7月龄时尿中亚硝酸盐/硝酸盐（NOx-）的排泄量，这是内源性一氧化氮生成的一个指标。在正常足月儿中，尿中NOx排泄量从1周龄到1月龄增加，然后下降直至4月龄，此后保持稳定。早产儿在1周龄时尿中NOx-排泄量显著高于足月儿。这一发现表明，与足月儿相比，早产儿的一氧化氮途径在生命早期可能被激活。根据本研究获得的参考值，这种尿液标志物现在可用于识别一氧化氮产生异常的婴儿。
