Hirakata Y, Katoh T, Tsukagoshi M, Hayashi M, Sugiyama Y, Kitamura S
Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.
Chemotherapy. 1997 Nov-Dec;43(6):400-5. doi: 10.1159/000239598.
We examined the bacterial colonization of the upper respiratory tract of 110 patients with primary lung cancer (PLC), 75 patients with nonmalignant lung diseases (NMLD) and 45 healthy volunteers (HV), comparing the sensitivity of expectorated sputum, and throat and nasal swabs. The frequency of bacterial colonization of the upper respiratory tract was significantly higher in the PLC patients (59.1%) than in NMLD patients (37.3%, p < 0.01) and HV (37.8%, p < 0.01). The frequency of gram-negative colonization was significantly higher in PLC patients than in the other subjects (p < 0.01). Expectorated sputum and nasal swab were the most sensitive for detection of whole bacteria and methicillin-resistant Staphylococcus aureus in the patients with PLC. Our results showed that PLC patients are significantly more frequently colonized by bacteria in their upper respiratory tracts and that a combination culture of expectorated sputum and nasal swab is suitable to estimate the bacterial colonization of the upper respiratory tract in the patients.
我们检查了110例原发性肺癌（PLC）患者、75例非恶性肺部疾病（NMLD）患者和45名健康志愿者（HV）的上呼吸道细菌定植情况，比较了咳出痰液、咽喉和鼻腔拭子的敏感性。PLC患者上呼吸道细菌定植频率（59.1%）显著高于NMLD患者（37.3%，p<0.01）和HV（37.8%，p<0.01）。PLC患者革兰氏阴性菌定植频率显著高于其他受试者（p<0.01）。咳出痰液和鼻腔拭子对检测PLC患者的全菌和耐甲氧西林金黄色葡萄球菌最为敏感。我们的结果表明，PLC患者上呼吸道细菌定植的频率显著更高，并且咳出痰液和鼻腔拭子的联合培养适合评估患者上呼吸道的细菌定植情况。
