Debongnie J C, Burette A, Glupczynski Y, De Prez C, De Koninck X, Donnay M
Service de Gastro-entérologie, Clinique St-Pierre, Ottignies, Bruxelles.
Acta Gastroenterol Belg. 1997 Jul-Sep;60(3):189-91.
In a series of 92 patients with gastric cancer who had biopsies of the antrum and fundus, we compared the 65 patients with Helicobacter pylori (71%) with the 27 negative patients. No difference was observed for age, gender or histology (intestinal or diffuse). Significant differences concerned location (11% of H. pylori positive patients had a cancer at the cardia or fundus vs 44%), the presence of a normal mucosa (3% vs 30%) and atrophy in the antrum (53% vs 17%). Seven of the ten patients with a normal mucosa had a cancer located at the cardia (p < 0.05) and in nine of the eleven patients younger than fifty, the cancer was of the diffuse type (p < 0.005). Thus, patients with H. pylori and gastric cancer differ from those uninfected. Of future concern is the large increase in cancers of the cardia, a cancer unassociated with H. pylori.
在一组92例接受胃窦和胃底活检的胃癌患者中，我们将65例幽门螺杆菌阳性患者（71%）与27例阴性患者进行了比较。在年龄、性别或组织学类型（肠型或弥漫型）方面未观察到差异。显著差异在于肿瘤位置（幽门螺杆菌阳性患者中11%的癌症位于贲门或胃底，而阴性患者为44%）、正常黏膜的存在情况（3%对30%）以及胃窦萎缩情况（53%对17%）。10例有正常黏膜的患者中有7例癌症位于贲门（p<0.05），在11例年龄小于50岁的患者中有9例癌症为弥漫型（p<0.005）。因此，幽门螺杆菌阳性的胃癌患者与未感染患者有所不同。未来令人担忧的是贲门癌的大幅增加，这是一种与幽门螺杆菌无关的癌症。
