Uehara F, Ohba N, Yonezawa S, Sato E
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Nov;101(11):866-73.
The distributional patterns of MUC 1 (the mucin whose cDNA was first cloned) and Keratin 14 (K14) in the invasive regions of malignant eyelid tumors were immunohistochemically examined by comparing with other histochemical markers. The MUC 1-positive tumor cells were detected in several serial, small, invasive tumor masses in the deep subepithelial region of the low differentiated carcinoma. They were also continuously detected in the border region between accumulated lymphocytes including T cells and tumor masses of the sebaceous carcinoma. On the other hand, K14-positive tumor cells were detected in the marginal regions of large tumor masses or those with smooth edges, some of which overlapped the distribution of MUC 1-positive cells in the tissues of undifferentiated carcinoma, squamous cell carcinoma, and sebaceous carcinoma. In general, MUC 1 may be expressed in the invasive tumor cells, whereas K14 may be expressed in the marginal cells of the stable, proliferating tumor masses.
通过与其他组织化学标志物进行比较，采用免疫组织化学方法检测了MUC 1（其cDNA首先被克隆的黏蛋白）和角蛋白14（K14）在恶性眼睑肿瘤浸润区域的分布模式。在低分化癌上皮下深层区域的多个连续小浸润性肿瘤块中检测到MUC 1阳性肿瘤细胞。在包括T细胞的聚集淋巴细胞与皮脂腺癌肿瘤块之间的边界区域也持续检测到它们。另一方面，在大肿瘤块的边缘区域或边缘光滑的肿瘤块中检测到K14阳性肿瘤细胞，其中一些在未分化癌、鳞状细胞癌和皮脂腺癌组织中与MUC 1阳性细胞的分布重叠。一般来说，MUC 1可能在浸润性肿瘤细胞中表达，而K14可能在稳定增殖的肿瘤块的边缘细胞中表达。
