Tanaka T, Ichiba Y, Miura Y, Koide K, Matsugu Y, Kodo Y, Fujii T, Ito H, Dohi K
Second Department of Surgery, Hiroshima University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1997 Nov;94(11):739-45.
Histopathological findings were examined in the models of chronic pancreatitis. Using mongrel dogs, we prepared a control group (group C), a chronic ischemic group (group I), an alcohol administration group (group A), a duct obstruction group (group O), and an alcohol + obstruction group (group AO). Group I showed severe inflammatory cell infiltration, fibrosis, fat replacement and loss of acinar cells. Group A showed no change. In group O, mild periductal fibrosis was recognized. Group AO showed moderate inter-lobular fibrosis and inflammatory cell infiltration, resembling those of human chronic alcoholic pancreatitis.
在慢性胰腺炎模型中检查组织病理学结果。使用杂种犬，我们制备了一个对照组（C组）、一个慢性缺血组（I组）、一个酒精给药组（A组）、一个导管阻塞组（O组）和一个酒精+阻塞组（AO组）。I组显示出严重的炎症细胞浸润、纤维化、脂肪替代和腺泡细胞丢失。A组无变化。在O组中，可见轻度导管周围纤维化。AO组显示中度小叶间纤维化和炎症细胞浸润，类似于人类慢性酒精性胰腺炎。
1）慢性缺血组的组织学结果比O组和AO组更严重。2）不完全导管阻塞的酒精给药模型是人类慢性酒精性胰腺炎的有用模型。
