Kawabata K, Nio Y, Imamura M
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Anticancer Drugs. 1997 Sep;8(8):790-6. doi: 10.1097/00001813-199709000-00009.
5-Fluorouracil (5-FU) has been an accepted effective against colorectal cancer, but combination regimens resulted in a lesser effect than 5-FU alone. The present study was designed to evaluate the efficiency of various combination chemotherapies, including 5-FU, on human colorectal cancer xenograft lines (CC-KK and RC-TK), which had been passed by transplantation in nude mice. Eight anticancer agents [5-FU, mitomycin C (MMC), adriamycin (ADR), 4'-epirubicin (EPIR), carboquone (CQ), cisplatin, carboplatin and etoposide (VP-16)] and their combinations were evaluated at 2-4 times the clinical dose. When the agents were administered singly, 5-FU, EPIR and CQ were effective against CC-KK, and 5-FU, MMC, EPIR, ADR, CQ and carboplatin were effective against RC-TK. Of the two-agent combinations including 5-FU, cisplatin + 5-FU was the most effective against both CC-KK and RC-TK. However, of the three-agent combinations, only cisplatin + 5-FU + MMC was more effective against both lines than cisplatin + 5-FU. These results suggest that cisplatin + 5-FU + MMC may be the most useful regimen against colorectal cancers in clinical application.
5-氟尿嘧啶（5-FU）一直被认为是治疗结直肠癌的有效药物，但联合用药方案的效果却不如单独使用5-FU。本研究旨在评估包括5-FU在内的各种联合化疗方案对人结直肠癌异种移植瘤系（CC-KK和RC-TK）的疗效，这些瘤系已在裸鼠体内通过移植传代。以临床剂量的2-4倍评估了8种抗癌药物[5-FU、丝裂霉素C（MMC）、阿霉素（ADR）、表柔比星（EPIR）、卡波醌（CQ）、顺铂、卡铂和依托泊苷（VP-16）]及其组合。当单独给药时，5-FU、EPIR和CQ对CC-KK有效，5-FU、MMC、EPIR、ADR、CQ和卡铂对RC-TK有效。在包括5-FU的两药组合中，顺铂+5-FU对CC-KK和RC-TK均最有效。然而，在三药组合中，只有顺铂+5-FU+MMC对这两种瘤系比顺铂+5-FU更有效。这些结果表明，顺铂+5-FU+MMC可能是临床应用中治疗结直肠癌最有效的方案。
