Tseng C C, Nio Y, Shiraishi T, Tsubono M, Morimoto H, Kawabata K, Masai Y, Tun T, Fukumoto M, Tobe T
First Department of Surgery, Kyoto University, Japan.
Anticancer Drugs. 1991 Oct;2(5):457-64. doi: 10.1097/00001813-199110000-00004.
Two human gastric cancer xenograft lines (GC-YN and GC-SF) transplanted in nude mice were employed to evaluate and compare the anticancer effect of seven single anticancer agents and their various combinations. Mitomycin C, cisplatin (Briplatin) (CDDP) and 5-fluorouracil (5-FU) were screened out to be effective against GC-YN and only epirubicin (Farmorubicin) (EPIR) was effective against GC-SF. Combinations of two of these 'effective' agents revealed that FP (5-FU + CDDP) is the most effective two-agent combination regimen against both lines, and some of those 'ineffective' single agents showed synergistic effects against both lines when combined with 5-FU. Moreover, three-agent combinations composed of FP and one of the other five agents were also evaluated to select out the most effective regimen. All the combinations showed higher inhibition on the tumor growth of GC-YN than FP regimen, and FP + adriamycin (Adriacin) (ADR) and FP + EPIR were more effective against GC-SF than FP. However, taking toxic effects into consideration, the results suggest that CDDP + 5-FU + EPIR (FPEPIR) may be the regimen most worthy of clinical trial in the chemotherapy against human gastric cancer.
将两个人胃癌异种移植瘤系（GC-YN和GC-SF）接种于裸鼠，用于评估和比较7种单一抗癌药物及其不同组合的抗癌效果。筛选出丝裂霉素C、顺铂（乐沙定）（CDDP）和5-氟尿嘧啶（5-FU）对GC-YN有效，而仅表柔比星（法玛新）（EPIR）对GC-SF有效。这些“有效”药物中两种药物的组合显示，FP（5-FU + CDDP）是针对两种瘤系最有效的双药联合治疗方案，并且一些“无效”的单一药物与5-FU联合时对两种瘤系均显示出协同作用。此外，还评估了由FP和其他五种药物之一组成的三药联合方案，以选出最有效的方案。所有组合对GC-YN肿瘤生长的抑制作用均高于FP方案，且FP + 阿霉素（阿霉素）（ADR）和FP + EPIR对GC-SF的疗效优于FP。然而，考虑到毒性作用，结果表明顺铂 + 5-氟尿嘧啶 + 表柔比星（FPEPIR）可能是在人胃癌化疗中最值得进行临床试验的方案。
