Nevo Y, Pestronk A
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
J Infect Dis. 1997 Dec;176 Suppl 2:S154-6. doi: 10.1086/513784.
Antecedent Campylobacter jejuni infection, detected by serologic tests, has been implicated in some acute immune polyneuropathies (AIP). Antibodies to Helicobacter pylori, C. jejuni, and GM1 ganglioside were measured in sera from 35 Chinese patients with AIP. Anti-GM1 antibodies were found in 54% of C. jejuni-seropositive, H. pylori-seronegative patients. In contrast, anti-GM1 antibodies were rare in sera that were either seropositive for both C. jejuni and H. pylori (P = .04) or seronegative for C. jejuni (P = .01). Motor axonal AIP was more common in the C. jejuni-seropositive, H. pylori-seronegative patients (82%) than in the bacterial antibody-negative group (38%). It was concluded that in AIP patients, C. jejuni-positive sera may be polyreactive, in that it may also react with H. pylori. In this situation, the specificity for either infection requires further validation. In contrast, sera with specific C. jejuni seropositivity are associated with both motor axonal AIP and selective serum IgG anti-GM1 antibodies.
血清学检测发现，既往空肠弯曲菌感染与某些急性免疫性多神经病（AIP）有关。检测了35例中国AIP患者血清中抗幽门螺杆菌、空肠弯曲菌和GM1神经节苷脂的抗体。在54%的空肠弯曲菌血清阳性、幽门螺杆菌血清阴性的患者中发现了抗GM1抗体。相比之下，在空肠弯曲菌和幽门螺杆菌均血清阳性（P = 0.04）或空肠弯曲菌血清阴性（P = 0.01）的血清中，抗GM1抗体很少见。运动轴索性AIP在空肠弯曲菌血清阳性、幽门螺杆菌血清阴性的患者中（82%）比在细菌抗体阴性组（38%）更常见。得出的结论是，在AIP患者中，空肠弯曲菌阳性血清可能具有多反应性，因为它也可能与幽门螺杆菌发生反应。在这种情况下，任何一种感染的特异性都需要进一步验证。相比之下，具有特异性空肠弯曲菌血清阳性的血清与运动轴索性AIP和选择性血清IgG抗GM1抗体均相关。
