Tongiani R, Malvaldi G, Lopez M, Puccinelli E
Histochemistry. 1976 Apr 21;47(1):1-21. doi: 10.1007/BF00492989.
The orderly organization in a number of discrete classes of weight persists in the hepatocytes during acute and chronic poisoning with thioacetamide and during a prolonged treatment with hydrocortisone, though many striking cytological and structural changes occur in the liver. The number of hepatocyte classes decreases under hydrocortisone treatment and during acute and chronic thioacetamide poisoning, and increases during recovery after acute thioacetamide poisoning and during the late phases of chronic thioacetamide poisoning. This is due to decrements and increments in dry mass of the hepatocytes, which occur by steps, through repeated losses and additions of a constant amount of solids substantially corresponding to the class period. Such a mechanism is similar to that acting in the hepatocyte atrophy due to starvation and in the hepatocyte enlargement occurring during postnatal development. Therefore, the increment and the decrement in dry mass by defined steps takes place in the hepatocytes in both physiological and pathological conditions.
在硫代乙酰胺急性和慢性中毒以及氢化可的松长期治疗期间，尽管肝脏出现了许多显著的细胞学和结构变化，但肝细胞中若干离散重量类别的有序组织依然存在。在氢化可的松治疗以及硫代乙酰胺急性和慢性中毒期间，肝细胞类别数量减少，而在硫代乙酰胺急性中毒后的恢复期间以及硫代乙酰胺慢性中毒的后期，肝细胞类别数量增加。这是由于肝细胞干质量的减少和增加，其通过步骤发生，通过反复损失和添加基本上与类别期相对应的恒定数量的固体物质。这种机制类似于饥饿导致的肝细胞萎缩以及出生后发育期间发生的肝细胞增大中起作用的机制。因此，在生理和病理条件下，肝细胞中干质量都以确定的步骤增加和减少。
