妇科癌症中的端粒酶

Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.

Obstet Gynecol. 1997 Dec;90(6):1015-9. doi: 10.1016/s0029-7844(97)00499-7.

OBJECTIVE

To provide the obstetrician-gynecologist with the following: 1) basic concepts of telomere shortening and telomerase activation and their relation to cellular immortalization and cancer, 2) an overview of potential uses of telomerase activity in cancer diagnosis, assessment of prognosis, and the development of new anticancer therapeutic approaches, and 3) a review of the literature on telomerase activity in gynecologic cancers.

DATA SOURCES

A computerized search for articles published in which telomerase or telomerases were included as a subject heading or a textword was performed using the Ovid Search Software (Ovid Technologies Inc., New York, NY). The search was conducted of the following databases of the National Library of Medicine and the National Cancer Institute: MEDLINE January 1966 to May 1997, HealthSTAR January 1975 to May 1997, AIDSline January 1980 to May 1997, and CancerLit January 1980 to May 1997. Additional sources were identified through cross-referencing.

METHODS OF STUDY SELECTION

All sources identified were reviewed with particular attention to human application, specifically in gynecologic cancers.

TABULATION, INTEGRATION, AND RESULTS: A total of 304 references was identified. Each reference was reviewed to determine the relevant contribution to the basic understanding of the role of telomerase in cellular immortalization and the development of cancer, potential uses of telomerase measurement in cancer, gynecologic applications, and potential use of telomerase inhibitors in cancer therapy.

CONCLUSION

Telomerase activity might be a valuable diagnostic and prognostic tool in gynecologic and other types of cancer, and telomerase inhibition might prove to be a significant therapeutic approach for some types of cancer. Better understanding of the relation between telomerase activation, tumor suppressor genes, and oncogenes might clarify several aspects of early tumorigenesis and result in development of novel approaches to early cancer detection and prevention.

目的

为妇产科医生提供以下内容：1）端粒缩短和端粒酶激活的基本概念及其与细胞永生化和癌症的关系；2）端粒酶活性在癌症诊断、预后评估及新抗癌治疗方法开发中的潜在用途概述；3）关于妇科癌症中端粒酶活性的文献综述。

资料来源

使用Ovid搜索软件（纽约州纽约市的Ovid Technologies公司）对以端粒酶或端粒酶作为主题词或文本词发表的文章进行计算机检索。检索了美国国立医学图书馆和美国国立癌症研究所的以下数据库：1966年1月至1997年5月的MEDLINE、1975年1月至1997年5月的HealthSTAR、1980年1月至1997年5月的AIDSline以及1980年1月至1997年5月的CancerLit。通过交叉引用确定了其他来源。