Parmley W W
Department of Medicine, University of California, USA.
Cardiology. 1997;88 Suppl 3:27-31. doi: 10.1159/000177503.
Angina pectoris due to coronary artery disease is a common manifestation of myocardial ischemia. Reduction of oxygen demand (beta-blockers) and relief of coronary vasoconstriction (calcium blocker or nitrate) are additive approaches to controlling ischemia. Risk factor reduction may improve coronary vascular physiology, and ASA reduces the likelihood of thrombosis and myocardial infarction. It is still unclear whether reduction of angina reduces cardiac morbidity and/or mortality. In the Asymptomatic Cardiac Ischemia Pilot Study (ACIP) and Total Ischemic Burden Bisoprolol Study (TIBBS) trials, data suggest benefit from reducing myocardial ischemia. Thus control of angina pectoris is a major goal of the treatment of coronary artery disease.
冠状动脉疾病所致心绞痛是心肌缺血的常见表现。降低氧需求（β受体阻滞剂）和缓解冠状动脉血管收缩（钙通道阻滞剂或硝酸盐）是控制缺血的联合方法。降低危险因素可能改善冠状动脉血管生理功能，阿司匹林可降低血栓形成和心肌梗死的可能性。目前尚不清楚心绞痛的减轻是否能降低心脏发病率和/或死亡率。在无症状心肌缺血初步研究（ACIP）和比索洛尔总缺血负荷研究（TIBBS）试验中，数据表明减轻心肌缺血有益。因此，控制心绞痛是冠状动脉疾病治疗的主要目标。
