Wu J C, Bell K, Najafi A, Widmark C, Keator D, Tang C, Klein E, Bunney B G, Fallon J, Bunney W E
Department of Psychiatry, University of California, Irvine College of Medicine, USA.
Neuropsychopharmacology. 1997 Dec;17(6):402-9. doi: 10.1016/S0893-133X(97)00089-4.
It has been hypothesized that a decrease in dopaminergic presynaptic activity during abstinence or withdrawal is related to relapse in cocaine-dependent subjects (Dackis and Gold 1985; Markou and Koob 1991). This study measured striatal 6-fluorodopa (6-FDOPA) uptake, an index of dopaminergic presynaptic activity, using positron emission tomography (PET) in 11 drug-free cocaine addicts compared to eight normal subjects. Middle abstinence cocaine addicts (n = 5, off cocaine 11-30 days) had significantly lower striatal 6-FDOPA uptake compared to normal controls or early abstinence cocaine addicts (n = 6, off cocaine 1-10 days). The cocaine-dependent subjects (n = 11) showed a significant negative correlation between days off cocaine and striatal 6-FDOPA uptake. The results suggest that during abstinence from cocaine there is a delayed decrease in dopamine terminal activity in the striatum.
据推测，在戒断或脱瘾期间多巴胺能突触前活动的降低与可卡因依赖者的复吸有关（达基斯和戈尔德，1985年；马尔库和库布，1991年）。本研究使用正电子发射断层扫描（PET）测量了11名无毒品可卡因成瘾者与8名正常受试者的纹状体6-氟多巴（6-FDOPA）摄取量，这是多巴胺能突触前活动的一个指标。与正常对照组或早期戒断可卡因成瘾者（n = 6，戒断可卡因1-10天）相比，中期戒断可卡因成瘾者（n = 5，戒断可卡因11-30天）的纹状体6-FDOPA摄取量显著降低。可卡因依赖者（n = 11）显示，戒断可卡因的天数与纹状体6-FDOPA摄取量之间存在显著负相关。结果表明，在戒除可卡因期间，纹状体中多巴胺终末活动存在延迟降低。
