ATP合酶：一种具有旋转机制的电化学转换器。

ATP synthase: an electrochemical transducer with rotatory mechanics.

作者信息

Junge W, Lill H, Engelbrecht S

机构信息

Universität Osnabrück, Abt. Biophysik, Germany.

出版信息

Trends Biochem Sci. 1997 Nov;22(11):420-3. doi: 10.1016/s0968-0004(97)01129-8.

DOI:10.1016/s0968-0004(97)01129-8

PMID:9397682

Abstract

ATP synthase (F0F1-ATPase) uses proton- or sodium-motive force to produce ATP form ADP and P(i). Three lines of experiment have recently demonstrated large-scale intersubunit rotation during ATP hydrolysis by F1. We discuss how ion flow through the membrane-intrinsic portion, F0, may generate torque and how this might be transmitted between stator and rotor to finally expel spontaneously formed ATP from F1 into water.

摘要

ATP合酶（F0F1 - ATP酶）利用质子动力或钠动力从二磷酸腺苷（ADP）和无机磷酸（P(i)）生成ATP。最近有三项实验表明，在F1催化ATP水解过程中存在大规模的亚基间旋转。我们将讨论离子如何通过膜内在部分F0产生扭矩，以及这种扭矩如何在定子和转子之间传递，最终将自发形成的ATP从F1排出到水溶液中。