Cdc37p对类固醇激素受体激活的体内差异调节。
Differential in vivo regulation of steroid hormone receptor activation by Cdc37p.
作者信息
Fliss A E, Fang Y, Boschelli F, Caplan A J
机构信息
Department of Cell Biology and Anatomy, Mount Sinai Medical Center, New York, New York 10029, USA.
出版信息
Mol Biol Cell. 1997 Dec;8(12):2501-9. doi: 10.1091/mbc.8.12.2501.
Abstract
The CDC37 gene is essential for the activity of p60(v-src) when expressed in yeast cells. Since the activation pathway for p60(v-src) and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37 gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed.
摘要
CDC37基因对于p60(v-src)在酵母细胞中表达时的活性至关重要。由于p60(v-src)和类固醇激素受体的激活途径相似，本研究分析了在表达CDC37基因突变体的酵母细胞中雄激素受体和糖皮质激素受体的激素依赖性反式激活作用。在这种突变体中，雄激素受体的激素依赖性反式激活在允许温度和限制温度下均存在缺陷，尽管糖皮质激素受体的反式激活仅在限制温度下有轻微缺陷。Cdc37p似乎通过雄激素受体配体结合域发挥作用，尽管它不影响受体激素结合亲和力。文中讨论了Cdc37p对类固醇激素受体的调节模型。
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本文引用的文献
1
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Trends Endocrinol Metab. 1997 Sep;8(7):271-5. doi: 10.1016/s1043-2760(97)00079-9.
2
Cdc37: a protein kinase chaperone?Cdc37：一种蛋白激酶伴侣？
Trends Cell Biol. 1997 Apr;7(4):157-61. doi: 10.1016/S0962-8924(97)01027-1.
3
Cdc37 is a molecular chaperone with specific functions in signal transduction.Cdc37是一种在信号转导中具有特定功能的分子伴侣。
Genes Dev. 1997 Jul 15;11(14):1775-85. doi: 10.1101/gad.11.14.1775.
4
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Cell Stress Chaperones. 1996 Dec;1(4):237-50. doi: 10.1379/1466-1268(1996)001<0237:apomci>2.3.co;2.
5
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Biochemistry. 1997 Mar 25;36(12):3600-7. doi: 10.1021/bi9612529.
6
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7
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8
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10
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