Shibata K, Osawa M, Iwata M
Department of Neurology, Tokyo Women's Medical College, Japan.
Cephalalgia. 1997 Nov;17(7):742-7. doi: 10.1046/j.1468-2982.1997.1707742.x.
We recorded full-field pattern reversal electroretinograms (PERGs) and visual evoked potentials (PVEPs) simultaneously in 15 migraine with aura, 14 migraine without aura patients during the interictal period, and in 23 sex- and age-matched normal subjects. All subjects had normal visual fields. The visual aura in all patients was hemianopsia or fortification spectra. Neither migraine group showed significant differences from normal in latency and amplitude of PERGs. In migraine with aura, the amplitudes of PVEPs in classic migraine at the mid-occipital electrode were significantly (p < 0.01) higher than normal. PVEP amplitudes were significantly (p < 0.01) higher on the contralateral side of the aura than the ipsilateral side in both visual aura and normal subjects, but there was no significant difference in latency. This high amplitude and asymmetry of PVEPs may contribute to defective inhibition between interhemispheric visual occipital areas or striate and peristriate areas.
我们同时记录了15例有先兆偏头痛患者、14例无先兆偏头痛患者发作间期的全视野图形翻转视网膜电图（PERG）和视觉诱发电位（PVEP），并与23名年龄和性别匹配的正常受试者进行对比。所有受试者视野均正常。所有患者的视觉先兆均为偏盲或闪光暗点。两组偏头痛患者的PERG潜伏期和波幅与正常组相比均无显著差异。有先兆偏头痛患者中，典型偏头痛患者枕叶中部电极处的PVEP波幅显著高于正常组（p<0.01）。在有视觉先兆的患者和正常受试者中，先兆对侧PVEP波幅均显著高于同侧（p<0.01），但潜伏期无显著差异。PVEP的这种高波幅和不对称性可能是由于半球间视觉枕叶区域或纹状区与纹周区之间抑制功能缺陷所致。
