Lane P W, Beamer T C, Myers D D
J Hered. 1976 May-Jun;67(3):135-8. doi: 10.1093/oxfordjournals.jhered.a108687.
A new recessive mutation, myd, causing a diffuse and progressive myopathy in the mouse is described. Histopathological comparisons with normal littermates showed widely distributed focal lesions in all skeletal muscles of myd/myd. Body and organ weights of affected mice were considerably less than those of normal littermates and the mean lifespan of myodystrophic mice that survived weaning was 17 weeks with a range of 5 to 39 weeks. Myodystrophy is located on chromosome 8; it is linked to Os with about 6 percent and to Eso with about 37 percent recombination.
本文描述了一种新的隐性突变基因myd，该基因可导致小鼠出现弥漫性进行性肌病。与正常同窝小鼠的组织病理学比较显示，myd/myd小鼠的所有骨骼肌中均有广泛分布的局灶性病变。患病小鼠的体重和器官重量明显低于正常同窝小鼠，断奶后存活的肌营养不良小鼠的平均寿命为17周，范围为5至39周。肌营养不良基因位于8号染色体上；它与Os的连锁率约为6%，与Eso的重组率约为37%。
