Hancock K W, Stitch S R, Chapman C
Clin Endocrinol (Oxf). 1979 Dec;11(6):611-8. doi: 10.1111/j.1365-2265.1979.tb03115.x.
A mongol child suffereing from hypothyroidism who presented with precocious puberty is described. A presumptive diagnosis of idiopathic precocious puberty was first made and she was treated initially with medroxyprogesterone acetate, and later, with cyproterone acetate. The diagnosis of primary hypothyroidism was made late because of misleading results of protein bound iodine estimations. Subsequently, thyroid medication resulted in a prompt return to the normal range of the previously elevated levels of plasma gonadotrophins, thyroid stimulating hormone and plasma and urinary oestrogens, but the serum prolactin remained elevated for several months after therapy was begun.
本文描述了一名患有甲状腺功能减退症且出现性早熟的蒙古儿童。最初推测为特发性性早熟，并先用醋酸甲羟孕酮治疗，后改用醋酸环丙孕酮治疗。由于蛋白结合碘测定结果产生误导，原发性甲状腺功能减退症的诊断较晚。随后，甲状腺药物治疗使之前升高的血浆促性腺激素、促甲状腺激素以及血浆和尿雌激素水平迅速恢复到正常范围，但开始治疗后血清催乳素仍持续升高了几个月。
