Galbraith D B, Kollar E J
J Exp Zool. 1976 Jul;197(1):135-40. doi: 10.1002/jez.1401970116.
Embryonic mouse tooth germs treated with L-azetidine-2-carboxylic acid cease their development, undergo a regression of the enamel organ, and do not maintain the histological characteristics of the explanted dental organ. On the other hand if procollagen is added exogenously to explants continously treated with L-azetidine, the effects of the inhibitor are not seen and the tissue is maintained. Thus, exogenously supplied procollagen supports morphogenesis in tooth rudiments that are unable to synthesize procollagen.
用L-氮杂环丁烷-2-羧酸处理的胚胎小鼠牙胚会停止发育，牙釉质器官发生退化，并且无法维持外植牙器官的组织学特征。另一方面，如果将原胶原蛋白外源添加到持续用L-氮杂环丁烷处理的外植体中，则不会观察到抑制剂的作用，组织得以维持。因此，外源供应的原胶原蛋白可支持无法合成原胶原蛋白的牙胚中的形态发生。
