Erlenmeyer-Kimling L, Adamo U H, Rock D, Roberts S A, Bassett A S, Squires-Wheeler E, Cornblatt B A, Endicott J, Pape S, Gottesman I I
Department of Medical Genetics, New York State Psychiatric Institute, NY, USA.
Arch Gen Psychiatry. 1997 Dec;54(12):1096-102. doi: 10.1001/archpsyc.1997.01830240052008.
The New York High-Risk Project is a study of offspring of patients with schizophrenia (HRSz group) or affective illness (HRAff group) and psychiatrically normal parents (NC group) observed prospectively from childhood to adulthood. We herein present lifetime prevalence and comorbidity rates of Axis I disorders in subjects and their siblings from sample A of the project.
Schedule for Affective Disorders and Schizophrenia-Lifetime Version interviews conducted with the offspring in adulthood were used to obtain diagnoses of Axis I disorders.
Schizophrenia and unspecified psychoses occurred only in the HRSz group. However, schizoaffective and psychotic affective disorders occurred equally in the HRSz and HRAff groups. Total rates of psychosis in these groups were significantly higher than in the NC group. All groups had similar rates of nonpsychotic affective and substance abuse disorders. The HRAff group, however, had significantly more total affective illness than the NC group and tended to have more anxiety disorders than the other groups. Comorbidity rates in the HRSz and HRAff groups were nearly twice those of the NC group.
The familial liabilities to schizophrenia and affective disorders show specificities and commonalities, differing markedly from each other in their expression of some disorders and sharing others. Patterns of comorbidity are generally, although not entirely, similar to these liabilities.
纽约高危项目是一项对精神分裂症患者（HRSz组）或情感障碍患者（HRAff组）的后代以及精神正常的父母（NC组）从童年到成年进行前瞻性观察的研究。我们在此呈现该项目样本A中受试者及其兄弟姐妹的轴I障碍终生患病率和共病率。
使用对成年后代进行的情感障碍与精神分裂症访谈日程表-终生版来获取轴I障碍的诊断。
精神分裂症和未特定的精神病仅发生在HRSz组。然而，分裂情感性障碍和精神病性情感障碍在HRSz组和HRAff组中出现的频率相同。这些组中的精神病总发生率显著高于NC组。所有组的非精神病性情感障碍和物质滥用障碍发生率相似。然而，HRAff组的情感疾病总数显著多于NC组，且焦虑症发生率往往高于其他组。HRSz组和HRAff组的共病率几乎是NC组的两倍。
精神分裂症和情感障碍的家族易感性呈现出特异性和共性，在某些障碍的表现上彼此显著不同，而在其他方面则有共同之处。共病模式总体上（尽管并非完全）与这些易感性相似。
