Wickramaratne P J, Weissman M M
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Eur Arch Psychiatry Clin Neurosci. 1993;243(3-4):150-7. doi: 10.1007/BF02190721.
Methods for investigating the nature of comorbidity of two psychiatric disorders, where each disorder is known to be familial, using family studies are described. The methods consist of using a study design which include relatives of four proband groups, namely probands with the pure form of each disorder, probands with the comorbid form of the disorders, and control probands who have neither of the disorders. Disorders in relatives were classified to parallel the disorder categories in probands. Patterns of transmission of these disorders between probands and relatives hypothesized under various models of comorbidity, and statistical methods for formally testing these hypothesis are described. These methods are illustrated, by applying them to data from a recent family study to investigate the relationship and the cause of comorbidity between panic disorder and major depressive disorder.
本文描述了利用家族研究调查两种已知具有家族性的精神疾病共病性质的方法。这些方法包括使用一种研究设计，该设计涵盖四类先证者的亲属，即患有每种疾病单纯形式的先证者、患有两种疾病共病形式的先证者以及两种疾病都没有的对照先证者。亲属中的疾病分类与先证者中的疾病类别相对应。描述了在各种共病模型下假设的这些疾病在先证者和亲属之间的传递模式，以及用于正式检验这些假设的统计方法。通过将这些方法应用于最近一项家族研究的数据，以调查惊恐障碍和重度抑郁症之间的关系及共病原因，对这些方法进行了说明。
