Chao H, Bowers J L, Holtzman D, Mulkern R V
Harvard-MIT Science and Technology Division, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
J Magn Reson Imaging. 1997 Nov-Dec;7(6):1048-55. doi: 10.1002/jmri.1880070617.
Rapid acquisition with relaxation enhancement (RARE) sequences have been used to map the 31P phosphocreatine (PCr) signal in human forearms at 4.7 T. Signal-to-noise levels of approximately 10 were achieved from the major muscle groups in 5.5-minute scan times with a spatial resolution of 4 x 2 x 2 cm3. Exercise caused demonstrable reductions in PCr signal from activated muscles, which correlated with affected muscle groups in T2-weighted proton images. RARE imaging of the PCr signal at 4.7 T is feasible and, with technically achievable improvements in signal-to-noise ratio, should prove useful in studying energy metabolism in muscle and other organs.
快速采集与弛豫增强（RARE）序列已被用于在4.7T磁场下绘制人体前臂的31P磷酸肌酸（PCr）信号。在5.5分钟的扫描时间内，从主要肌肉群获得了约10的信噪比，空间分辨率为4×2×2cm3。运动导致激活肌肉的PCr信号明显降低，这与T2加权质子图像中受影响的肌肉群相关。4.7T磁场下PCr信号的RARE成像可行，并且随着信噪比在技术上可实现的提高，应该会在研究肌肉和其他器官的能量代谢方面证明是有用的。
