Ramachandran A, Snehalatha C, Vijay V, Satyavani K, Latha E, Haffner S M
Diabetes Research Centre, Royapuram, Madras, India.
Diabet Med. 1997 Nov;14(11):937-41. doi: 10.1002/(SICI)1096-9136(199711)14:11<937::AID-DIA502>3.0.CO;2-S.
Plasma leptin concentrations were measured in 144 non-diabetic men and women (age 21-73 years, BMI 14.8-37.7 kg m(-2)), in fasting samples collected during a population survey for diabetes mellitus. Leptin, fasting and 2-h post-glucose load plasma concentrations of glucose and immunoreactive insulin were measured. In a subset of 50 normoglycaemic individuals, subcutaneous fat (SF) and visceral fat (VF) areas at L4-L5 level were also measured by CT. As in other populations, women had significantly higher plasma leptin concentrations than men (p < 0.001) but the values were similar in normal (NGT) and impaired glucose tolerance (IGT). Geometric mean concentrations of leptin in men and women with NGT were 4.8 and 17.7 ng ml(-1), respectively, and the corresponding values in IGT were 6.2 and 19.0 ng ml(-1). Multiple regression analysis in the total group showed that the leptin concentration (log-transformed) was strongly dependent on sex (R2 = 53.4%), BMI (R2 = 17.4%), and to a lesser degree on the 2-h plasma insulin (R2 = 2.4%) and the WHR (R2 = 0.8%). In men, the total abdominal fat showed a strong association with leptin (R2 = 49.3%) and in women the subcutaneous fat area showed a similar effect (R2 = 39.5%). It is likely that subcutaneous and not visceral fat may be a determinant of plasma leptin in Asian Indians, and the correlation between leptin and insulin resistance may be less strong than in other ethnic groups.
在一项糖尿病群体调查期间收集的空腹样本中，对144名非糖尿病男性和女性（年龄21 - 73岁，体重指数14.8 - 37.7 kg/m²）测量了血浆瘦素浓度。测量了瘦素、空腹及葡萄糖负荷后2小时的血浆葡萄糖和免疫反应性胰岛素浓度。在50名血糖正常个体的子集中，还通过CT测量了L4 - L5水平的皮下脂肪（SF）和内脏脂肪（VF）面积。与其他人群一样，女性的血浆瘦素浓度显著高于男性（p < 0.001），但在正常糖耐量（NGT）和糖耐量受损（IGT）人群中，瘦素值相似。NGT男性和女性的瘦素几何平均浓度分别为4.8和17.7 ng/ml，IGT人群中的相应值分别为6.2和19.0 ng/ml。对整个群体的多元回归分析表明，瘦素浓度（对数转换后）强烈依赖于性别（R² = 53.4%）、BMI（R² = 17.4%），在较小程度上依赖于2小时血浆胰岛素（R² = 2.4%）和腰臀比（R² = 0.8%）。在男性中，腹部总脂肪与瘦素显示出强相关性（R² = 49.3%），在女性中，皮下脂肪面积显示出类似的影响（R² = 39.5%）。在亚洲印度人中，皮下脂肪而非内脏脂肪可能是血浆瘦素的决定因素，并且瘦素与胰岛素抵抗之间的相关性可能不如其他种族群体强。
