Veterans Affairs Medical Center, University of California-San Francisco, CA 94115, USA.
Int J Obes (Lond). 2012 Jun;36(6):810-6. doi: 10.1038/ijo.2011.167. Epub 2011 Aug 23.
To investigate whether leptin and adiponectin are associated with body fat composition in a South Asian population independent of metabolic variables.
Cross-sectional study.
150 South Asian men and women, between the ages of 45-79 years, in the San Francisco Bay Area without pre-existing clinical cardiovascular disease.
Blood samples were obtained to measure glucose metabolism variables, lipid profiles and adipokines. Total body fat was determined using dual-energy X-ray absorptiometry. Abdominal computed tomography was used to measure subcutaneous, visceral and hepatic fat.
Average body mass index (BMI) was overweight at 26.1±4.6 kg m(-2) and did not differ by sex. However, women had significantly more total body fat (P<0.001) and subcutaneous fat (P<0.001) than men, whereas men had significantly more visceral fat (P<0.001) and hepatic fat (P=0.04) than women. Women had significantly higher levels of adiponectin (P<0.01) and leptin (P<0.01). In sex-stratified analyses, leptin was strongly associated with all-body composition measures in women (P<0.05) as well as in men (P<0.05 except for hepatic fat), whereas there was an insignificant trend towards an inverse association between adiponectin and body composition in both women and men, which was significant in combined bivariate analyses. In multivariate analyses, leptin was strongly associated with all measures of adiposity, including BMI (P<0.001), total body fat (P<0.001), visceral fat (P<0.001) and hepatic fat (P=0.01). However, adiponectin's inverse association with adiposity was significantly attenuated by high-density lipoprotein (HDL), triglycerides and insulin resistance. The association between adipokines and diabetes was markedly attenuated after adjusting for body composition.
Despite only modestly elevated BMI, South Asians have elevated levels of total and regional adiposity. Leptin is strongly associated with adiposity, whereas adiponectin's association with adiposity is attenuated by metabolic variables in South Asians. Adipokines in association with adiposity have an important role in the development of diabetes.
研究在南亚人群中，瘦素和脂联素与体脂肪成分的关系是否独立于代谢变量。
横断面研究。
150 名年龄在 45-79 岁之间、无既往临床心血管疾病的旧金山湾区南亚男性和女性。
采集血样以测量葡萄糖代谢变量、血脂谱和脂肪细胞因子。采用双能 X 射线吸收法测定全身脂肪量。采用腹部计算机断层扫描测量皮下脂肪、内脏脂肪和肝脂肪。
平均体质指数（BMI）为超重 26.1±4.6 kg/m²，且性别间无差异。然而，女性的全身脂肪量（P<0.001）和皮下脂肪量（P<0.001）显著高于男性，而男性的内脏脂肪量（P<0.001）和肝脂肪量（P=0.04）显著高于女性。女性的脂联素水平显著较高（P<0.01），瘦素水平显著较高（P<0.01）。在按性别分层分析中，瘦素与女性（P<0.05）以及男性（P<0.05，除肝脂肪外）的全身脂肪成分各指标均呈强烈相关，而脂联素与女性和男性的体成分之间呈负相关趋势，但在联合双变量分析中具有统计学意义。在多变量分析中，瘦素与所有肥胖指标均呈强烈相关，包括 BMI（P<0.001）、全身脂肪量（P<0.001）、内脏脂肪量（P<0.001）和肝脂肪量（P=0.01）。然而，高密度脂蛋白（HDL）、甘油三酯和胰岛素抵抗显著减弱了脂联素与肥胖的负相关关系。在调整体成分后，脂联素与糖尿病的关系明显减弱。
尽管南亚人的 BMI 仅略有升高，但他们的全身和局部脂肪量却较高。瘦素与肥胖密切相关，而脂联素与肥胖的关系在南亚人群中受到代谢变量的影响。脂肪细胞因子与肥胖相关，在糖尿病的发生发展中具有重要作用。
