发酵乳杆菌从L-精氨酸的两个等效胍基氮合成一氧化氮。
Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum.
作者信息
Morita H, Yoshikawa H, Sakata R, Nagata Y, Tanaka H
机构信息
School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
出版信息
J Bacteriol. 1997 Dec;179(24):7812-5. doi: 10.1128/jb.179.24.7812-7815.1997.
Abstract
Ten strains of Lactobacillus fermentum that differed in origin converted metmyoglobin to nitrosylmyoglobin [a pentacoordinate nitric oxide (NO) complex of Fe(II) myoglobin] in MRS broth at pH 4.3. Of the 10 strains, L. fermentum IFO 3956 possessed the strongest capacity to convert metmyoglobin to nitrosylmyoglobin. This strain synthesizes NO enzymatically from the two equivalent guanidino nitrogens of L-arginine. To our knowledge, this demonstrates for the first time the production of NO synthesized from the guanidino nitrogens of L-arginine by lactic acid bacteria. IFO 3956 may possess a bacterial NO synthase.
摘要
十株来源不同的发酵乳杆菌在pH 4.3的MRS肉汤中可将高铁肌红蛋白转化为亚硝酰肌红蛋白[Fe(II)肌红蛋白的五配位一氧化氮(NO)配合物]。在这10株菌中，发酵乳杆菌IFO 3956将高铁肌红蛋白转化为亚硝酰肌红蛋白的能力最强。该菌株可从L-精氨酸的两个等效胍基氮中酶促合成NO。据我们所知，这首次证明了乳酸菌可从L-精氨酸的胍基氮中合成NO。IFO 3956可能拥有一种细菌型一氧化氮合酶。
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