C/EBPα基因敲除小鼠的凝血因子IX水平。
Clotting factor IX levels in C/EBP alpha knockout mice.
作者信息
Davies N, Austen D E, Wilde M D, Darlington G J, Brownlee G G
机构信息
Chemical Pathology Unit, Sir William Dunn School of Pathology, University of Oxford.
出版信息
Br J Haematol. 1997 Dec;99(3):578-9. doi: 10.1046/j.1365-2141.1997.4603263.x.
Abstract
Previous studies have indicated that C/EBP alpha is involved in the regulation of factor IX and mutations of a C/EBP recognition element in the factor IX promoter result in haemophilia B. We now report that mice homozygous for the deletion of the c/ebp alpha gene are significantly deficient in factor IX transcription.
摘要
先前的研究表明，C/EBPα参与因子IX的调控，且因子IX启动子中C/EBP识别元件的突变会导致B型血友病。我们现在报告，c/ebpα基因缺失的纯合小鼠在因子IX转录方面存在显著缺陷。
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