Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.
Laboratory of Bioinformatics Approaches in Combinatorial Chemistry and Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Int J Mol Sci. 2021 Dec 28;23(1):322. doi: 10.3390/ijms23010322.
Obesity and type 2 diabetes are both significant contributors to the contemporary pandemic of non-communicable diseases. Both disorders are interconnected and associated with the disruption of normal homeostasis in adipose tissue. Consequently, exploring adipose tissue differentiation and homeostasis is important for the treatment and prevention of metabolic disorders. The aim of this work is to review the consecutive steps in the postnatal development of adipocytes, with a special emphasis on in vivo studies. We gave particular attention to well-known transcription factors that had been thoroughly described in vitro, and showed that the in vivo research of adipogenic differentiation can lead to surprising findings.
肥胖症和 2 型糖尿病都是非传染性疾病当代流行的重要因素。这两种疾病相互关联，并与脂肪组织中正常内稳态的破坏有关。因此，探索脂肪组织分化和内稳态对于代谢紊乱的治疗和预防很重要。本工作的目的是综述出生后脂肪细胞发育的连续步骤，特别强调体内研究。我们特别关注了在体外得到充分描述的众所周知的转录因子，并表明体内脂肪生成分化的研究可以得出令人惊讶的发现。
